Budesonide Suppresses Pulmonary Antibacterial Host Defense by Down-Regulating Cathelicidin-Related Antimicrobial Peptide
作者： Xi Dai , Guoping Li
DOI: 10.4172/2471-9552.1000122
关键词:
摘要: Some previous evidences have proven that Inhaled Corticosteroids (ICS) increased a risk factor for pneumonia in asthma. However, it remains unclear ICS impacts the antibacterial host defence of lung We aim to explore direct impact glucocorticoids on against bacterial during examined effect budesonide P. aeruginosa and Cathelicidin-Related Antimicrobial Peptide (CRAMP) HDM-challenged mice epithelial cell lines. found inhaled aeruginosainduced inflammation OVA-challenged mice. reduced production CRAMP Total CFUs were significantly higher MLE-12 cells exposed budesonide. The was dose-dependent. Collectively, these findings demonstrated suppressed pulmonary depending downregulation
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