Maternal viral load, CD4 cell count and vertical transmission of HIV-1

摘要: HIV load and CD4 cell numbers were measured among 95 infected women during pregnancy in order to determine their value as prognostic markers for transmission of virus from mother infant. Among the 94 live births, 13 children with HIV, 69 uninfected 12 unknown infection status. RNA levels, by nucleic acid sequence based amplification, significantly higher (P < 0.001) who transmitted than those did not transmit maternal viral was a stronger predictor number. The predicted rate relative 2% at 1,000 copies, 11% 10,000 copies 40% 100,000 copies/ml. Little variation occurred there an association between prematurity, mean gestation delivery decreasing 1.3 weeks every 10-fold increase = 0.007). This study demonstrates that high level is risk factor infant more marker High also associated premature delivery. Maternal therefore useful on which base management decisions pregnancy.