Decreased Basal Production of Nitric Oxide in Patients With Heart Disease
作者： Hiroyuki Sumino , Kunio Sato , Tetsuo Sakamaki , Hiroaki Masuda , Tetsuya Nakamura
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摘要: Study objectives The pathophysiologic role of nitric oxide (NO) released in the lung is not well understood. To determine whether production endogenous NO correlated with any hemodynamic parameters, we measured amount from tissue patients heart disease. Methods Twenty (14 ischemic disease, 4 dilated cardiomyopathy, and 2 mitral stenosis) 16 normal control subjects were enrolled study. We exhaled air samples by using a method developed our laboratory. release rate lungs was calculated duration exhalation. Results significantly lower moderate-to-severe failure (New York Heart Association [NYHA] II or III) than those mild (NYHA I) subjects. positively cardiac index (r=0.50, p Conclusions suggest that basal impaired, perhaps leading to elevated pulmonary vascular tone seen failure.
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