Human Bone Marrow Mesenchymal Stromal Cells Promote Bone Regeneration in a Xenogeneic Rabbit Model: A Preclinical Study.

摘要: Significant research efforts have been undertaken during the last decades to treat musculoskeletal disorders and improve patient’s mobility quality of life. The goal is return function as quickly completely possible. Cellular therapy has increasingly employed in this setting. design study was focused on cell-based alternatives. present aimed at investigating bone regeneration capacity xenogeneic human marrow-derived mesenchymal stromal cell (hMSC) implantation with tricalcium phosphate (TCP) granules an immunocompetent rabbit model critical-size defects femoral condyles. Two experimental groups, TCP hMSC + TCP, were compared. Combination hMSC did not affect viability or osteogenic differentiation. We also observed significantly higher vivo hMSC + TCP group, which displayed better osteointegration. Also, evidence contribution a osteointegration noticed. Finally, no inflammatory reaction detected, besides xenotransplantation cells into recipient. In summary, combined potential combination for purposes that provides preclinical results compared alone.