Plasma myostatin levels are related to the extent of right ventricular dysfunction in exacerbation of chronic obstructive pulmonary disease.

作者: Chun-Rong Ju , Jian-Heng Zhang , Miao Chen , Rong-Chang Chen

DOI: 10.1080/1354750X.2016.1203999

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摘要: AbstractObjective: To investigate the relationship between plasma myostatin levels and right ventricle (RV) dysfunction (RVD) in acute exacerbation of chronic obstructive pulmonary disease (AECOPD).Methods: The study recruited 84 patients with AECOPD. Plasma was analyzed tricuspid annular plane systolic excursion (TAPSE) < 16 mm used as main indicator for RVD.Results: were significantly higher 47 RVD than 37 ones without (P < 0.005). Multivariate regression analysis revealed that correlated TAPSE values RV myocardial performance index (p < 0.001) among patients.Conclusion: is a potential biomarker improving diagnosis

参考文章(43)
Hanno H. Leuchte, Rainer A. Baumgartner, Michal El Nounou, Michael Vogeser, Claus Neurohr, Michael Trautnitz, Juergen Behr, Brain Natriuretic Peptide Is a Prognostic Parameter in Chronic Lung Disease American Journal of Respiratory and Critical Care Medicine. ,vol. 173, pp. 744- 750 ,(2006) , 10.1164/RCCM.200510-1545OC
Jørgen Vestbo, Suzanne S. Hurd, Alvar G. Agustí, Paul W. Jones, Claus Vogelmeier, Antonio Anzueto, Peter J. Barnes, Leonardo M. Fabbri, Fernando J. Martinez, Masaharu Nishimura, Robert A. Stockley, Don D. Sin, Roberto Rodriguez-Roisin, Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease American Journal of Respiratory and Critical Care Medicine. ,vol. 187, pp. 347- 365 ,(2013) , 10.1164/RCCM.201204-0596PP
Nazzareno Galiè, Marius M Hoeper, Marc Humbert, Adam Torbicki, Jean-Luc Vachiery, Joan Albert Barbera, Maurice Beghetti, Paul Corris, Sean Gaine, J Simon Gibbs, Miguel Angel Gomez-Sanchez, Guillaume Jondeau, Walter Klepetko, Christian Opitz, Andrew Peacock, Lewis Rubin, Michael Zellweger, Gerald Simonneau, Alec Vahanian, Angelo Auricchio, Jeroen Bax, Claudio Ceconi, Veronica Dean, Gerasimos Filippatos, Christian Funck-Brentano, Richard Hobbs, Peter Kearney, Theresa McDonagh, Keith McGregor, Bogdan A Popescu, Zeljko Reiner, Udo Sechtem, Per Anton Sirnes, Michal Tendera, Panos Vardas, Petr Widimsky, Udo Sechtem, Nawwar Al Attar, Felicita Andreotti, Michael Aschermann, Riccardo Asteggiano, Ray Benza, Rolf Berger, Damien Bonnet, Marion Delcroix, Luke Howard, Anastasia N Kitsiou, Irene Lang, Aldo Maggioni, Jens Erik Nielsen-Kudsk, Myung Park, Pasquale Perrone-Filardi, Suzanna Price, Maria Teresa Subirana Domenech, Anton Vonk-Noordegraaf, Jose Luis Zamorano, None, Guidelines for the diagnosis and treatment of pulmonary hypertension: the Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT) European Heart Journal. ,vol. 30, pp. 2493- 2537 ,(2009) , 10.1093/EURHEARTJ/EHP297
Werner Seeger, Yochai Adir, Joan Albert Barberà, Hunter Champion, John Gerard Coghlan, Vincent Cottin, Teresa De Marco, Nazzareno Galiè, Stefano Ghio, Simon Gibbs, Fernando J. Martinez, Marc J. Semigran, Gerald Simonneau, Athol U. Wells, Jean-Luc Vachiéry, Pulmonary Hypertension in Chronic Lung Diseases Journal of the American College of Cardiology. ,vol. 62, pp. D109- D116 ,(2013) , 10.1016/J.JACC.2013.10.036
S. Chua, R. A. Levine, C. Yosefy, M. D. Handschumacher, J. Chu, A. Qureshi, J. Neary, T.-T. Ton-Nu, M. Fu, C. J. Wu, J. Hung, Assessment of right ventricular function by real-time three-dimensional echocardiography improves accuracy and decreases interobserver variability compared with conventional two-dimensional views European Journal of Echocardiography. ,vol. 10, pp. 619- 624 ,(2009) , 10.1093/EJECHOCARD/JEP013
Joerg Heineke, Mannix Auger-Messier, Jian Xu, Michelle Sargent, Allen York, Stephen Welle, Jeffery D. Molkentin, Genetic Deletion of Myostatin From the Heart Prevents Skeletal Muscle Atrophy in Heart Failure Circulation. ,vol. 121, pp. 419- 425 ,(2010) , 10.1161/CIRCULATIONAHA.109.882068
SHOICHI MIYAMOTO, NORITOSHI NAGAYA, TORU SATOH, SHINGO KYOTANI, FUMIO SAKAMAKI, MASATOSHI FUJITA, NORIFUMI NAKANISHI, KUNIO MIYATAKE, Clinical correlates and prognostic significance of six-minute walk test in patients with primary pulmonary hypertension. Comparison with cardiopulmonary exercise testing. American Journal of Respiratory and Critical Care Medicine. ,vol. 161, pp. 487- 492 ,(2000) , 10.1164/AJRCCM.161.2.9906015
E. Zakynthinos, Z. Daniil, J. Papanikolaou, D. Makris, Pulmonary hypertension in COPD: pathophysiology and therapeutic targets. Current Drug Targets. ,vol. 12, pp. 501- 513 ,(2011) , 10.2174/138945011794751483
Edward Eden, Ruth Minkin, Adil Shujaat, Pulmonary hypertension and chronic cor pulmonale in COPD. International Journal of Chronic Obstructive Pulmonary Disease. ,vol. 2, pp. 273- 282 ,(2007)
Gonzalez-Cadavid N, Sinha-Hikim I, Bhasin S, Zachwieja Jj, Smith, Plasma myostatin-immunoreactive protein is increased after prolonged bed rest with low-dose T3 administration. Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology. ,vol. 6, pp. 11- ,(1999)