Sample size requirements for addressing the population genetic issues of forensic use of DNA typing.

摘要: DNA typing offers a unique opportunity to identify individuals for medical and forensic purposes. Probabilistic inference regarding the chance occurrence of match between type an evidentiary sample that accused suspect, however, requires reliable estimation genotype allele frequencies in population. Although population-based data on at several hypervariable loci are being accumulated various laboratories, rigorous treatment size needed such purposes has not been made from population genetic considerations. It is shown here potentially most useful identification have intrinsic property they involve large number segregating alleles, great majority these alleles rare. As consequence, because possible genotypes offer maximum potential individualization, observe all large. In fact, so even if huge could be sampled, it guaranteed was drawn single homogeneous Therefore adequate genotypic probabilities must based frequencies, represent far more reasonable. Further economization one wants representation only frequent sample, rare can approximated by upper bound applications.