The Rapalogue, CCI-779, improves salivary gland function following radiation.

摘要: The standard of care for head and neck cancer typically includes surgical resection the tumor followed by targeted radiation. However depending on location stage, some cases may not require while others be treated with chemoradiation. Unfortunately, these radiation treatments cause chronic negative side effects patients. These are associated damage to surrounding normal salivary gland tissue include xerostomia, changes in taste malnutrition. underlying mechanisms radiation-induced dysfunction unknown, however, rodent models persistently elevated proliferation is correlated reduced stimulated flow. rapalogue, CCI-779, has been used other cell systems induce autophagy reduce proliferation, therefore aim this study was determine if CCI-779 could utilized ameliorate dysfunction. Four six week old Atg5f/f; Aqp5-Cre, Atg5+/+; Aqp5-Cre FVB mice were chloroquine, or DMSO post-radiation. Stimulated flow rates determined parotid submandibular tissues collected analyses. Mice a defect autophagy, via conditional knockout Atg5 glands, display increased compensatory acinar compartment hypertrophy at 24-72 hours following post-therapy have significant improvements physiology as rates, indices amylase production secretion. Consequently, post-radiation use allows improvement function reestablishment glandular homeostasis. As already FDA approved uses, it secondary alleviate patients who completed anti-tumor therapy.