Genetic and Environmental Variances of Bone Microarchitecture and Bone Remodeling Markers: A Twin Study

摘要: All genetic and environmental factors contributing to differences in bone structure between individuals mediate their effects through the final common cellular pathway of modeling remodeling. We hypothesized that account for most population variance cortical trabecular microstructure, particular intracortical porosity medullary size – void volumes (porosity), which establish internal surface areas or interfaces upon remodeling deposit remove configure microarchitecture. Microarchitecture distal tibia radius markers were measured 95 monozygotic (MZ) 66 dizygotic (DZ) white female twin pairs aged 40 61 years. Images obtained using high-resolution peripheral quantitative computed tomography analyzed StrAx1.0, a nonthreshold-based software quantifies matrix porosity. Genetic components estimated under assumptions classic model. The data consistent with proportion accounted by being: 72% 81% (standard errors ∼18%) tibial total, cortical, cross-sectional area (CSA); 67% 61% total porosity, before after adjusting CSA, respectively; 51% volumetric mineral density (vBMD; all p < 0.001). For corresponding traits, 47% 68% (all p ≤ 0.001). Cross-twin cross-trait correlations CSA higher MZ (rMZ = 0.49) than DZ (rDZ = 0.27) (p = 0.024), but not (p = 0.258), CSA. markers, accounting 55% 62% variance. infer middle-aged women differ microarchitecture more because environment. © 2014 American Society Bone Mineral Research.