Soft tissue sarcoma : epidemiology and prognosis in 508 patients

摘要: We have evaluated epidemiology, prognosis and the association between metastases local recurrence in a series of adult patients with soft tissue sarcoma (STS) extremity trunk wall. 508 were diagnosed Southern Swedish Health Care Region from 1964 through 1989. The was population-based, i.e., all within defined area included, irrespective where treated, thereby avoiding selection bias referral follow-up. Epidemiology. annual incidence 18 per million. median age 64 years. One third tumors subcutaneous, these smaller than deep-seated tumors. Malignant fibrous histiocytoma grade IV commonest. Differences noted clinicopathologic features among histotypes. 5-year metastasis-free survival rate (MFSR) 0.6. crude 0.3. majority recurrences occurred 3 pattern to tumor center has become more favorable over time; last 5 years half subcutaneous four fifths referred before surgery. Prognostic factors. Tumor size, necrosis, vascular invasion strong independent prognostic factors for metastasis histologically mixed series. In MFH, storiform pleomorphic subtype, necrosis size associated poor prognosis. independently worsened leiomyosarcoma. liposarcoma, synovial sarcoma, only important used system which identified two thirds MFSR 0.8 one Metastasis recurrence. causal proposed should be interpreted caution. suggest that highly malignant combine distant aggressiveness, is marker risk, not necessarily cause of, metastasis. Conclusions. 1. Population-based are preferable when studying epidemiology sarcoma. 2. propose reliable can improve accuracy. 3. There growing body evidence against relationship