The sensitizing capacity of composite plants. VII. Experimental studies with extracts and compounds of Chamomilla recutita (L.) Rauschert and Anthemis cotula L

摘要: A bibliographic review reveals that about 50 reports refer to allergic reactions following “chamomile”. However, only in five papers, the botanical identification of material allowed establish a correlation between observed lesions and suspicious plant species ( CHAMOMILLA RECUTITA). In majority other instances effects were caused by genus ANTHEMIS, frequently called “chamomile” as well. Experimental studies guinea pigs using rigorous sensitizing technique proved CH. RECUTITA (German chamomile) well KAMILLOSAN®, total extract from its bisabololtype, possess low capacity. Under identical test conditions bisabolol oxide B-chemotype has an evident moderate allergenic activity. Evidence was given chamomile allergy is due anthecotulid linear sesquiterpene lactone which detectable this chemical strain at variable but levels. Negative ascertained with further isolated compounds various lactones Compositae sensitized treated KAMILLOSAN®. Therefore, for pharmaceutical cosmetic purposes should be free lactone. Anthecotulid previously ANTHEMIS COTULA (Dog fennel, Stinking mayweed) concentrations up 7.3%, reason commonly primary irritant contact dermatitis specific species. Its yield German flowers does not induce irritations. Specific hypersensitivity might rarely induced B-type known chemotypes particular.