A 'rule of three' for fragment-based lead discovery?
作者： Miles Congreve , Robin Carr , Chris Murray , Harren Jhoti
DOI: 10.1016/S1359-6446(03)02831-9
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sci-hub.se 参考文章(10)
Tudor I. Oprea, Andrew M. Davis, Simon J. Teague, Paul D. Leeson, Is There a Difference between Leads and Drugs? A Historical Perspective Journal of Chemical Information and Computer Sciences. ,vol. 41, pp. 1308- 1315 ,(2001) , 10.1021/CI010366A
Dirk Vetter, Chemical microarrays, fragment diversity, label-free imaging by plasmon resonance?a chemical genomics approach Journal of Cellular Biochemistry. ,vol. 87, pp. 79- 84 ,(2002) , 10.1002/JCB.10408
David E Clark, Stephen D Pickett, Computational methods for the prediction of 'drug-likeness' Drug Discovery Today. ,vol. 5, pp. 49- 58 ,(2000) , 10.1016/S1359-6446(99)01451-8
Simon J. Teague, Andrew M. Davis, Paul D. Leeson, Tudor Oprea, The Design of Leadlike Combinatorial Libraries Angewandte Chemie International Edition. ,vol. 38, pp. 3743- 3748 ,(1999) , 10.1002/(SICI)1521-3773(19991216)38:24<3743::AID-ANIE3743>3.0.CO;2-U
Robin Carr, Harren Jhoti, Structure-based screening of low-affinity compounds Drug Discovery Today. ,vol. 7, pp. 522- 527 ,(2002) , 10.1016/S1359-6446(02)02245-6
Michael M. Hann, Andrew R. Leach, Gavin Harper, Molecular Complexity and Its Impact on the Probability of Finding Leads for Drug Discovery Journal of Chemical Information and Computer Sciences. ,vol. 41, pp. 856- 864 ,(2001) , 10.1021/CI000403I
Daniel F. Veber, Stephen R. Johnson, Hung-Yuan Cheng, Brian R. Smith, Keith W. Ward, Kenneth D. Kopple, Molecular properties that influence the oral bioavailability of drug candidates. Journal of Medicinal Chemistry. ,vol. 45, pp. 2615- 2623 ,(2002) , 10.1021/JM020017N
Joanna Owens, Chris Lipinski discusses life and chemistry after the Rule of Five Drug Discovery Today. ,vol. 8, pp. 12- 16 ,(2003) , 10.1016/S1359-6446(02)02556-4
Christopher A Lipinski, Franco Lombardo, Beryl W Dominy, Paul J Feeney, Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings Advanced Drug Delivery Reviews. ,vol. 46, pp. 3- 26 ,(1997) , 10.1016/S0169-409X(00)00129-0
D. A. Erlanson, A. C. Braisted, D. R. Raphael, M. Randal, R. M. Stroud, E. M. Gordon, J. A. Wells, Site-directed ligand discovery Proceedings of the National Academy of Sciences of the United States of America. ,vol. 97, pp. 9367- 9372 ,(2000) , 10.1073/PNAS.97.17.9367