Cerebral Perfusion Imaging with Gadolinium Chelates and Iron Oxides in Humans

摘要: Susceptibility-induced signal loss following the bolus injection of paramagnetic contrast agents coupled with dynamic magnetic resonance imaging (MRI) has enabled generation cerebral blood volume (CBV) maps which reflect perfusion [1-4]. Both gadolinium-and dysprosium-based and endogenous substances have been used for CBV functional MRI (fMRI) studies [1-6]. More recently, superparamagnetic iron oxides (SPIO) a stronger susceptibility effect than chelates applied in humans as well [7, 8]. We describe clinical results current approved dose gadolinium (0.1 mmol/kg body weight), present neutral chelate at higher doses (0.1-0.5 bodyweight), take look into future first novel bolus-injectable SPIO agent (Resovist, SH U 555A, Schering AG, Berlin) to induce brain [9].