Low-frequency Ultrasound Enhanced Transdermal Drug Delivery Across Rat Skin
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DOI: 10.4333/KPS.2007.37.6.365
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摘要: The primary aim of this study was to investigate the enhancement effect low-frequency ultrasound on skin permeation. In vitro permeation experiments were performed using Franz modified diffusion cells with ketoprofen as model drug. various factors-ultrasound application mode (continuous and discontinuous mode), intensity (0.26 , 0.29 ) duty cycle (3%, 16%, 50%, 83%) studied. highest observed at intensity, 50% cycle, mode. result suggested feasibility low frequency for phonophoretic transdermal drug delivery system.
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