Antivenomic Characterization of Two Antivenoms Against the Venom of the Taipan, Oxyuranus scutellatus, from Papua New Guinea and Australia
作者： María Herrera , Owen K Paiva , Ana Helena Pagotto , Alvaro Segura , Solange MT Serrano
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摘要: Antivenoms manufactured by bioCSL Limited (Australia) and Instituto Clodomiro Picado (Costa Rica) against the venom of taipan snakes (Oxyuranus scutellatus) from Australia Papua New Guinea (PNG), respectively, were compared using antivenomics, an analytical approach that combines proteomics with immunoaffinity chromatography. Both antivenoms recognized all proteins present in PNG O. scutellatus, although a pattern partial recognition was observed for some components. In case Australian scutellatus venom, both immunorecognized majority components, but CSL antivenom showed stronger immunoreactivity, which revealed percentage retained column. interacted taipoxin surface plasmon resonance. These observations on antivenomics agree previous neutralization studies.
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