Role of CXCR5 and CCR7 in Follicular Th Cell Positioning and Appearance of a Programmed Cell Death Gene-1High Germinal Center-Associated Subpopulation

摘要: Th cell access to primary B follicles is dependent on CXCR5. However, whether CXCR5 induction T cells sufficient in determining their follicular positioning has been unclear. In this study, we find that transgenic overexpression not promote entry of naive unless the counterbalancing influence CCR7 ligands removed. contrast, Ag-engaged at B/T boundary could occur absence The germinal center (GC) response was 2-fold reduced when lacked CXCR5, although these were able GC. Finally, CXCR5(high)CCR7(low) found have elevated IL-4 transcript and programmed death gene-1 (PD-1) expression, PD-1(high) or mice compromised GC formation. Overall, findings provide further understanding how changes expression regulate during Ab responses, they suggest development and/or maintenance a subset appropriate interaction with cells.