Histological insight into the pathogenesis of severe laryngomalacia

摘要: Objective: To correlate clinical and histological findings in patients with laryngomalacia who required surgical intervention. Methods: Retrospective study of all undergoing supraglottoplasty by a single surgeon (MEG) for severe between October, 1999 November, 2000. Results: Nine were identified, which seven had evidence GER. Seven co-existing abnormalities or delays neuromuscular development including seizure disorder, agenesis the corpus callosum, obstructive sleep apnea, primary aspiration, history apparent life-threatening events, craniosynostosis. Varying degrees subepithelial edema significant dilation lymphatics noted specimens. Submucosal inflammation was minimal to mild, intraepithelial rare absent sections. No submucosal gland hyperplasia seen samples from any patient. Two specimens contained cuneiform cartilage, both histologically characterized as fibrocartilage. Conclusions: In this series, histopathology tissue excised during treatment dominated lymphatic dilation. Further is needed investigate comorbidities that may contribute need intervention children laryngomalacia.