Synthesis of sildenafil analogues from anacardic acid and their phosphodiesterase-5 inhibition.
作者： R. Paramashivappa , P. Phani Kumar , P. V. Subba Rao , A. Srinivasa Rao
DOI: 10.1021/JF0258050
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摘要: Anacardic acid (6-pentadecylsalicylic acid), a major component of cashew nut shell liquid, consists heterogeneous mixture monoenes, dienes, and trienes. The enes anacardic was hydrogenated to saturated compound. Using as starting material, analogues sildenafil [a potent phosphodiesterase-5 (PDE5) inhibitor an orally active drug for the treatment erectile dysfunction] were synthesized, observe effect pentadecyl side chain on PDE5 inhibition. synthesized compounds characterized by spectral studies tested inhibition, results compared with those obtained sildenafil. Keywords: acid; liquid; sildenafil; inhibitor; dysfunction
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