Antinociception induced by rosuvastatin in murine neuropathic pain.
作者： Hugo F. Miranda , Fernando Sierralta , Nicolas Aranda , Paula Poblete , Rodrigo L. Castillo
DOI: 10.1016/J.PHAREP.2017.11.012
关键词:
摘要: Abstract Background Neuropathic pain, and subsequent hypernociception, can be induced in mice by paclitaxel (PTX) administration partial sciatic nerve ligation (PSNL). Its pharmacotherapy has been a clinical challenge, due to lack of effective treatment. In two models mouse neuropathic pain (PTX PSNL) the antinociception rosuvastatin participation proinflammatory biomarkers, interleukin (IL)- 1β, TBARS glutathione were evaluated. Methods A dose–response curve for ip was obtained on cold plate, hot plate Von Frey assays. Changes spinal cord levels IL-1β, lipid peroxidation measured at 7 14 days PTX PSNL murine models. Results or able induce peripheral neuropathy with either 14 days. Rosuvastatin dose dependent The increased IL-1β pretreatment reduced rosuvastatin. reduction glutathione, PSNL, expressed as ratio GSH/GSSG, significantly animals pretreated anti-inflammatory properties statins could underlie their beneficial effects biomarkers activation glia. Conclusion findings this study suggest potential usefulness treatment pain.
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Hugo F. Miranda, Viviana Noriega, Loreto Olavarria, Ramiro J. Zepeda, Fernando Sierralta, Juan C. Prieto, Antinociception and anti-inflammation induced by simvastatin in algesiometric assays in mice. Basic & Clinical Pharmacology & Toxicology. ,vol. 109, pp. 438- 442 ,(2011) , 10.1111/J.1742-7843.2011.00746.X
S. Nadeau, M. Filali, J. Zhang, B. J. Kerr, S. Rivest, D. Soulet, Y. Iwakura, J. P. de Rivero Vaccari, R. W. Keane, S. Lacroix, Functional Recovery after Peripheral Nerve Injury is Dependent on the Pro-Inflammatory Cytokines IL-1β and TNF: Implications for Neuropathic Pain The Journal of Neuroscience. ,vol. 31, pp. 12533- 12542 ,(2011) , 10.1523/JNEUROSCI.2840-11.2011
Luc Jasmin, Lynn Kohan, Michelle Franssen, Gabriella Janni, Jonathan R Goff, The cold plate as a test of nociceptive behaviors: description and application to the study of chronic neuropathic and inflammatory pain models Pain. ,vol. 75, pp. 367- 382 ,(1998) , 10.1016/S0304-3959(98)00017-7
RajKumar Venisetty, Shailaja Rondi, Ramu Peddolla, Neuro, cardio, and reno protective activities of rosuvastatin in streptozotocin-induced type 2 diabetic rats undergoing treatment with metformin and glimepiride Journal of advanced pharmaceutical technology & research. ,vol. 5, pp. 78- 83 ,(2014) , 10.4103/2231-4040.133429
Mahesh M. Ghaisas, Prasad R. Dandawate, Suyash A. Zawar, Yogesh S. Ahire, Santosh P. Gandhi, Antioxidant, antinociceptive and anti-inflammatory activities of atorvastatin and rosuvastatin in various experimental models Inflammopharmacology. ,vol. 18, pp. 169- 177 ,(2010) , 10.1007/S10787-010-0044-6
Annika B. Malmberg, Allan I. Basbaum, Partial sciatic nerve injury in the mouse as a model of neuropathic pain: behavioral and neuroanatomical correlates. Pain. ,vol. 76, pp. 215- 222 ,(1998) , 10.1016/S0304-3959(98)00045-1
Lorenzo Di Cesare Mannelli, Matteo Zanardelli, Paola Failli, Carla Ghelardini, Oxaliplatin-Induced Neuropathy: Oxidative Stress as Pathological Mechanism. Protective Effect of Silibinin The Journal of Pain. ,vol. 13, pp. 276- 284 ,(2012) , 10.1016/J.JPAIN.2011.11.009
Hiroshi Ohkawa, Nobuko Ohishi, Kunio Yagi, Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction Analytical Biochemistry. ,vol. 95, pp. 351- 358 ,(1979) , 10.1016/0003-2697(79)90738-3
Nicole Schupp, Ursula Schmid, August Heidland, Helga Stopper, Rosuvastatin protects against oxidative stress and DNA damage in vitro via upregulation of glutathione synthesis. Atherosclerosis. ,vol. 199, pp. 278- 287 ,(2008) , 10.1016/J.ATHEROSCLEROSIS.2007.11.016
Subramanian S. Parvathy, Willias Masocha, Matrix metalloproteinase inhibitor COL-3 prevents the development of paclitaxel-induced hyperalgesia in mice. Medical Principles and Practice. ,vol. 22, pp. 35- 41 ,(2013) , 10.1159/000341710