Heterogeneity of ovarian theca and interstitial gland cells in mice.

摘要: It has been established that two developmentally and functionally distinct cell types emerge within the mammalian testis adrenal gland throughout life. Fetal adult of steroidogenic cells (i.e., testicular Leydig adrenocortical cells) develop in prenatal postnatal period, respectively. Although ovary synthesizes steroids postnatally, presence fetal-type not described. We had previously transgenic mouse lines which fetal were labeled with an EGFP reporter gene by FLE (fetal enhancer) Ad4BP/SF-1 (Nr5a1) gene. In present study, we examined expression females found is turned on ovaries. A comparison expressions marker genes revealed expressed all but rather a proportion theca interstitial ovary. This finding was further supported experiments using BAC mice recapitulated endogenous expression. conclusion, our observations from this study strongly suggest ovarian consist at least types.