Analysis of circulating regulatory T cells in patients with metastatic prostate cancer pre- versus post-vaccination
作者： Matteo Vergati , Vittore Cereda , Ravi A. Madan , James L. Gulley , Ngar-Yee Huen
DOI: 10.1007/S00262-010-0927-9
关键词:
摘要: We have previously shown that the suppressive function of regulatory T cells (Tregs) from peripheral blood mononuclear (PBMCs) is enhanced in patients with prostate cancer when compared healthy individuals. Two phase II studies using PSA-TRICOM vaccine metastatic castration-resistant (mCRPC) showed evidence patient benefit terms survival. The Halabi nomogram has been used to predict survival (HPS) mCRPC treated conventional chemotherapy or second-line hormonal therapy. Tregs PBMCs (n = 23) were obtained pre- and post-three monthly vaccinations, analyzed for number, phenotype, function. Changes post- versus pre-vaccination these parameters 3-year HPS. No differences Treg numbers observed pre-vaccination. Trends (P 0.029) between overall (OS) a decrease also analyzing effector:Treg (CD4+CD25+CD127−FoxP3+CTLA4+) ratio OS These data provide preliminary possible association improved are after three vaccinations. Patients an > HPS more likely decreased following vaccine. Larger confirm extend findings warranted.
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