Aberrant DNA Double-strand Break Repair Threads in Breast Carcinoma: Orchestrating Genomic Insult Survival

摘要: Breast carcinoma is a heterogeneous disease that has exhibited rapid resistance to treatment in the last decade. Depending genotype and phenotype of breast cancer, there are discernible differences DNA repair protein responses including double strand break repair. It fact different molecular sub-types activate these dedicated pathways distinct manner. The double-strand damage machinery manipulated by selectively or insults inflicted genotoxic effects chemotherapy radiation therapy. two employed homologous recombination non-homologous end joining. In recent decades, therapeutic interventions targeting one more factors involved repairing breaks chemo/radiation therapy have been widely studied. Herein, this review paper summarizes evidence ongoing clinical trials citing potential combinatorial carcinoma.