Regulation of CART mRNA by stress and corticosteroids in the hippocampus and amygdala.
作者： Richard G. Hunter , Rudy Bellani , Erik Bloss , Ana Costa , Russell D. Romeo
DOI: 10.1016/J.BRAINRES.2007.03.042
关键词:
摘要: Abstract CART (Cocaine-Amphetamine-Regulated Transcript) has been shown to be regulated by corticosteroids in the hypothalamus, but its regulation and stress not well examined hippocampus or amygdala. Further, implicated transition puberty. In this study we examine effects of acute (30 min) on mRNA prepubescent adult rats. addition, chronic (21 day × 6 h) restraint upon expression amygdala 7 days adrenalectomy corticosteroid replacement these regions rat brain. We found an up-regulation central induced dentate gyrus stress. Adrenalectomy reduced effect was blocked corticosterone RU28,362 aldosterone replacement, suggesting a synergism mineralocorticoid glucocorticoid receptors. Our data establish that is regionally time specific manner actions hippocampus.
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