Reversal of Mitochondrial Transhydrogenase Causes Oxidative Stress in Heart Failure

作者: Alexander G. Nickel , Albrecht von Hardenberg , Mathias Hohl , Joachim R. Löffler , Michael Kohlhaas

DOI: 10.1016/J.CMET.2015.07.008

关键词:

摘要: … (P)H/NAD(P) + by FCCP was less pronounced than by H 2 O … NADPH/NADH ratios after FCCP by the ratios after cyanide, … the NADPH pool is more “uncoupled” from the NADH pool (…

参考文章(40)
Dao-Fu Dai, Edward J. Hsieh, Yonggang Liu, Tony Chen, Richard P. Beyer, Michael T. Chin, Michael J. MacCoss, Peter S. Rabinovitch, Mitochondrial proteome remodelling in pressure overload-induced heart failure: the role of mitochondrial oxidative stress Cardiovascular Research. ,vol. 93, pp. 79- 88 ,(2012) , 10.1093/CVR/CVR274
Véronique L. Roger, Epidemiology of Heart Failure Circulation Research. ,vol. 113, pp. 646- 659 ,(2013) , 10.1161/CIRCRESAHA.113.300268
Ting-Ting Huang, Mohammed Naeemuddin, Sailaja Elchuri, Mutsuo Yamaguchi, Heather M. Kozy, Elaine J. Carlson, Charles J. Epstein, Genetic modifiers of the phenotype of mice deficient in mitochondrial superoxide dismutase Human Molecular Genetics. ,vol. 15, pp. 1187- 1194 ,(2006) , 10.1093/HMG/DDL034
Giorgio Olivetti, Rakesh Abbi, Federico Quaini, Jan Kajstura, Wei Cheng, James A. Nitahara, Eugenio Quaini, Carla Di Loreto, Carlo A. Beltrami, Stanislaw Krajewski, John C. Reed, Piero Anversa, Apoptosis in the Failing Human Heart New England Journal of Medicine. ,vol. 336, pp. 1131- 1141 ,(1997) , 10.1056/NEJM199704173361603
P. H. Backx, H. E. Ter Keurs, Fluorescent properties of rat cardiac trabeculae microinjected with fura-2 salt. American Journal of Physiology-heart and Circulatory Physiology. ,vol. 264, ,(1993) , 10.1152/AJPHEART.1993.264.4.H1098
Anatoly A. Starkov, Gary Fiskum, Regulation of brain mitochondrial H2O2 production by membrane potential and NAD(P)H redox state Journal of Neurochemistry. ,vol. 86, pp. 1101- 1107 ,(2003) , 10.1046/J.1471-4159.2003.01908.X
Sonia Cortassa, Miguel A. Aon, Brian O’Rourke, Robert Jacques, Hsiang-Jer Tseng, Eduardo Marbán, Raimond L. Winslow, A computational model integrating electrophysiology, contraction, and mitochondrial bioenergetics in the ventricular myocyte Biophysical Journal. ,vol. 91, pp. 1564- 1589 ,(2006) , 10.1529/BIOPHYSJ.105.076174
Andrew Halestrap, A pore way to die Nature. ,vol. 434, pp. 578- 579 ,(2005) , 10.1038/434578A
Christoph Maack, Tanja Kartes, Heiko Kilter, Hans-Joachim Schäfers, Georg Nickenig, Michael Böhm, Ulrich Laufs, Oxygen Free Radical Release in Human Failing Myocardium Is Associated With Increased Activity of Rac1-GTPase and Represents a Target for Statin Treatment Circulation. ,vol. 108, pp. 1567- 1574 ,(2003) , 10.1161/01.CIR.0000091084.46500.BB