Regional arterial stiffness in central and peripheral arteries is differentially related to endothelial dysfunction assessed by brachial flow-mediated dilation in metabolic syndrome.

摘要: The interrelationship between endothelial function and arterial stiffness may be different for central peripheral arteries due to their structural functional differences. study aims assess the vascular haemodynamics in metabolic syndrome. Thirty-seven patients [63.0 (57.5-66.0) years, 68.4% males] of syndrome (National Cholesterol Education Program - Adult Treatment Panel-III criteria) were studied. Carotid-femoral, carotid-radial pulse wave velocity augmentation index (AIx@75) assessed using applanation tonometry. Endothelial was evaluated by brachial flow-mediated dilation B-mode ultrasonography. Central pressures measured radial tonometry sphygmomanometer, respectively. Carotid-radial correlated significantly with diastolic blood pressure ( r = 0.33, p = 0.04) inversely r = -0.61, p = 0.0001). AIx@75 carotid-femoral r = 0.35, p = 0.03) aortic r = 0.43, p = 0.01). In principal component analysis, an inverse relationship observed but not velocity. Regional central-elastic peripheral-muscular differentially relates dysfunction. might predominantly influenced dysfunction-induced changes, while are majorly affected alterations.