Physical activity and its effect on bone in the short- and long- term perspective.

摘要: Osteoporosis is a growing problem worldwide where Sweden has one of the highest fragility fracture incidences in world. The years are thought to be an opportune time build strong bones and enhancement peak bone mass (PBM) been suggested as prevention strategy for osteoporosis. Most exercise intervention studies children, evaluating accrual areal mineral density (aBMD), include volunteers use specifically designed osteogenic programs. aim prospective controlled paediatric osteoporosis (POP) study evaluate daily general curriculum-based program 40min/school day population-based cohort aged 7-9 at start. All children grades 1 2 school were invited 93% agreed participate. Age-matched from 3 nearby schools assigned ordinary Swedish curriculum 60 minutes per week served controls. Bone content (BMC; g) aBMD (g/cm2) measured with DXA total body, lumbar spine hip. size volumetric (vBMD; g/cm3) femoral neck third vertebrae (L3) calculated dual energy X-ray absorbtiometry (DXA) scans. A questionnaire previously used several but modified evaluated lifestyle factors. participants remained Tanner stage I during period. The data presented this thesis results first 99 girls 137 boys. There no differences between group controls baseline anthropometrics, parameters or factors such dietary habits, chronic diseases, ongoing medication, fractures, smoking alcohol intake. only difference found that control exercised more leisure (0.7 ± 0.7 vs. 1.3 1.6 h/week, p=0.02). After was initiated, spent on physical activity both compared mean annual gain width greater than In addition, there also groups body width. When all individuals gender specific included cohort, duration including school-based spare-time organized correlated L3 BMC, BMD No correlations parameters. In summary, POP-study show within seems associated benefits width, traits important strength. present already after year remains two period. This supports view moderately intense could recommended increase prepubertal children. If growth osteoporosis, must maintained old age when fractures occur. Our 22 active soccer players, 128 former players 138 age-matched controls, evaluates relationship age. by frequency obtained 284 568 identified computerized city files Malmo. Relative leg almost 12% higher players. During 35 following retirement diminution aBMD, estimated regression line, 0.33% 0.21% proportion had they below age, different groups. provides evidence biologically weight-bearing sites. suggests cessation may result loss benefit leaving modest residual middle perhaps none occurs. does not support notion vigorous young adulthood reduces risk However, we aware power data, later our group, larger sample size, have opposed view. Therefore, today reduced