The common adolescent bipolar phenotype shows positive biases in emotional processing

摘要: Rock PL, Goodwin GM, Harmer CJ. The common adolescent bipolar phenotype shows positive biases in emotional processing. Bipolar Disord 2010: 12: 606–615. © 2010 Authors. Journal compilation John Wiley & Sons A/S. Objectives:  disorder is associated with abnormalities processing that persist into periods of remission. However, studies euthymic patients may be confounded by the experience mood episodes and medication. We therefore assessed an group for vulnerability markers phenotype. Methods:  Mood Disorder Questionnaire (MDQ) a screening tool targets mood-elevation symptoms. selected 32 high-scoring students (≥ 7 symptoms) 30 low-scoring controls (≤ 3 screened them Mini International Neuropsychiatric Interview–Plus other psychiatric disorders. investigated assessing facial expression recognition, memory, emotion-potentiated startle, dot-probe task. Results:  Of high-MDQ participants, 12 were remission from defined DSM-IV-TR interview (bipolar II disorder/bipolar not otherwise specified) major depressive disorder. High-MDQ participants had higher levels neuroticism, low mood, lifetime anxiety comorbidity alcohol dependence compared low-MDQ participants. showed facilitated recognition surprised neutral expressions enhanced versus negative information memory startle. There no effects on categorisation/recall or attentional bias task. Conclusions:  These results suggest show despite increased anxiety. Such represent psychological marker phenotype.