Genetic identification by mass spectrometric analysis of single-nucleotide polymorphisms: ternary encoding of genotypes.
作者： Timothy J. Griffin , Lloyd M. Smith
DOI: 10.1021/AC991390E
关键词:
摘要: An approach to genetic identification using biallelic single-nucleotide polymorphism (SNP) markers is described in which the three possible genotypes, AA, Aa, or aa, where “A” and “a” represent two SNP alleles, are assigned a ternary (base 3) digit of 0, 1, 2, respectively. Genotyping an individual over panel separate produces composite code that can be converted easily stored, decimal 10) number. The unambiguous 11 individuals demonstrated codes generated from MALDI-TOF mass spectrometric genotyping data 7 different markers.
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