Timing of dietary fat exposure and mammary tumorigenesis: Role of estrogen receptor and protein kinase C activity

摘要: The possible association between a high fat diet and increased breast cancer risk has remained controversial. This largely reflects the conflicting data obtained from migrant, case control animal studies, which generally support this association, cohort studies often fail to show link cancer. mammary gland is particularly sensitive estrogens during fetal development, leading us hypothesize that dietary levels period may significantly influence risk. Using chemically-induced tumors in rats as our experimental model, we have demonstrated ability of maternal diet, polyunsaturated fatty acid (PUFA) linoleic acid, alter differentiation, accelerate onset sexual maturation, increase glands female exposed highfat utero more undifferentiated structures (terminal end buds) fewer differentiated (alveolar than low-fat utero. Furthermore, these contain lower total estrogen receptors reduced protein kinase C activity. These effects appear be mediated by an tne serum estradiol pregnancy, are elevated at least 30% pregnant dams fed diet. administration produce on puberty sensitivity chemical carcinogenesis comparable those seen offspring pregnancy. Our results, thus, hypothesis based epidemiological daughters' results also suggest high-fat important factor increasing pregnancy estrogenic