Cell Biology of Lymphatic Metastasis The Potential Role of c-erbB Oncogene Signalling

作者: S. A. Eccles

DOI: 10.1007/978-3-642-57151-0_5

关键词:

摘要: Lymphatic metastases are an important indicator of the malignancy epithelial cancers. Empirical clinical observations associating specific genetic abnormalities with tumour progression, allied basic laboratory investigations, providing not only improved prognostic and diagnostic opportunities, but also a detailed understanding molecular machinery metastasis. One such association — between c-erbB oncogene family metastasis has proved particularly instructive. Functional links over-expression (and occasionally mutational activation) c-erbB-1 (EGFR) c-erbB-2 phenotypes metastatic cells have been elucidated. Activated oncogenes potentiate cell adhesion to endothelial upregulate VEGF, potentially facilitating angiogenesis vascular invasion. In addition, over-expressing these frequently show aberrant cell-cell cell-matrix interactions, mediated by changes in integrin cadherin function. Thirdly, both EGFR signalling can significantly matrix metalloproteinases, key enzymes involved angiogenes is Finally, receptors linked actin cytoskeleton highly expressed on invadopodia, thought assist migration. Taken together, suggest that act as “master switches” metastasis, whose activation co-ordinately controls events normally utilised development, now subverted cell. As such, they represent ideal targets for therapeutic intervention.

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