THE INFLUENCE OF LIPID COMPOSITION AND CAROTENE ON LIPID PEROXIDATION IN LIPOSOMES
作者： Mohammad N. Sarbolouki , Vahid Saneei , Pegah Maghdooni Bagheri
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摘要: Oxidative damage to membrane lipid is one of the prime events occurring in aging and other undesirable physiological processes. In this study experiments were performed on liposomes (prepared either from crude erythrocyte phospholipids or purified egg yolk phosphatidylcholine) as models bilayer portion biomembranes. The effects β-carotene, phospholipid composition peroxidation process, initiated by Fe 2+ , studied. It was found that β-carotene does not show any noticeable antioxidant effect process prepared phosphatides, whereas it effectively suppressed same phosphatidylcholine (EYPC). concluded anti-/pro-oxidant activity β–carotene also dependent may provide an explanation about conflicting reports its role ordinary promoted oxidation experiments.
参考文章(36)
Paola Palozza, Soundos Moulla, Norman I. Krinsky, Effects of beta-carotene and alpha-tocopherol on radical-initiated peroxidation of microsomes. Free Radical Biology and Medicine. ,vol. 13, pp. 127- 136 ,(1992) , 10.1016/0891-5849(92)90074-Q
D.C. Borg, K.M. Schaich, Iron and hydroxyl radicals in lipid oxidation: Fenton reactions in lipid and nucleic acids co-oxidized with lipid ,(1987)
Hermann Esterbauer, Kevin H. Cheeseman, DETERMINATION OF ALDEHYDIC LIPID PEROXIDATION PRODUCTS: MALONALDEHYDE AND 4-HYDROXYNONENAL Methods in Enzymology. ,vol. 186, pp. 407- 421 ,(1990) , 10.1016/0076-6879(90)86134-H
O.P. Heinonen, D. Albanes, The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers The New England Journal of Medicine. ,vol. 330, pp. 1029- 1035 ,(1994)
T.A. Kennedy, D.C. Liebler, Peroxyl radical scavenging by beta-carotene in lipid bilayers. Effect of oxygen partial pressure. Journal of Biological Chemistry. ,vol. 267, pp. 4658- 4663 ,(1992) , 10.1016/S0021-9258(18)42884-0
Norman S. Radin, Extraction of tissue lipids with a solvent of low toxicity. Methods in Enzymology. ,vol. 72, pp. 5- 7 ,(1981) , 10.1016/S0076-6879(81)72003-2
K.M. Schaich, D.C. Borg, Iron and iron derived radicals ,(1987)
Susan Taylor Mayne, Beta-carotene, carotenoids, and disease prevention in humans. The FASEB Journal. ,vol. 10, pp. 690- 701 ,(1996) , 10.1096/FASEBJ.10.7.8635686
R Stocker, Y Yamamoto, A. McDonagh, A. Glazer, B. Ames, Bilirubin is an antioxidant of possible physiological importance Science. ,vol. 235, pp. 1043- 1046 ,(1987) , 10.1126/SCIENCE.3029864
Alan A. Woodall, George Britton, Malcolm J. Jackson, CAROTENOIDS AND PROTECTION OF PHOSPHOLIPIDS IN SOLUTION OR IN LIPOSOMES AGAINST OXIDATION BY PEROXYL RADICALS: RELATIONSHIP BETWEEN CAROTENOID STRUCTURE AND PROTECTIVE ABILITY Biochimica et Biophysica Acta. ,vol. 1336, pp. 575- 586 ,(1997) , 10.1016/S0304-4165(97)00007-X