Aryl substituted pyrazoles, triazoles and tetrazoles, and the use thereof
作者： Derk J. Hogenkamp , Phong Nguyen , Ji Yang
DOI:
关键词:
摘要: This invention relates to compounds having the Formula (I) or a pharmaceutically acceptable salt, prodrug solvate thereof, wherein Het and R5 - R8 are set in specification. The also is directed use of for treatment neuronal damage following global focal ischemia, prevention neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), treatment, amelioration both acute chronic pain, antitinnitus agents, anticonvulsants, antimanic depressants, local anesthetics, antiarrhythmics diabetic neuropathy.
lens.org 参考文章(60)
Møller Ar, Similarities between chronic pain and tinnitus. American Journal of Otology. ,vol. 18, pp. 577- 585 ,(1997)
Lawrence I. Kruse, Processes for preparing 4-substituted indoles ,(1981)
Pankaja K. Kadaba, Aryl substituted 1H-4,5-dihydro-1,2,3-triazoles as anticonvulsants ,(1984)
Nwe Y. BaMaung, Frank L. Wagenaar, Noah P. Tu, Jay R. Luly, Stevan W. Djuric, Xun Zhou, Richard J. Sciotti, Earl J. Gubbins, Anwer Basha, David J. Madar, Paul E. Wiedeman, Usha Warrior, Pyrazole inhibitors of cytokine production ,(1999)
David John Carini, John Jonas Vytautas Duncia, Gregory James Wells, Substituted pyrrole, pyrazole and triazole angiotensin II antagonists. ,(1989)
Masaaki Matsuo, Kiyoshi Tsuji, Takashi Ogino, Nobukiyo Konishi, Pyrazole derivatives with antiinflammatory, analgesic and antithrombolic activity ,(1993)
Rajashekhar Betageri, Xiao-Jun Wang, Karl Hargrave, Rajiv Sharma, Sanxing Sun, Thomas M. Parks, Charles L. Cywin, Mary Ann Hoermmann, John R. Proudfoot, Thomas M. Kirrane, Usha R. Patel, Substituted 1-(4-aminophenyl)pyrazoles and their use as anti-inflammatory agents ,(1999)
Masaaki Matsuo, Nobukiyo Konishi, Kiyoshi Tsuji, Katsuya Nakamura, Pyrazole derivatives, and pharmaceutical composition comprising the same ,(1990)
John F. Lambert, Timothy Norris, Megan E. Hnatow, Process for making 5-lipoxygenase inhibitors having varied heterocyclic ring systems ,(2000)
Y Ohizumi, H Nakamura, J Kobayashi, W A Catterall, Specific inhibition of [3H] saxitoxin binding to skeletal muscle sodium channels by geographutoxin II, a polypeptide channel blocker. Journal of Biological Chemistry. ,vol. 261, pp. 6149- 6152 ,(1986) , 10.1016/S0021-9258(19)84540-4