Four‐year study of cobalt and chromium blood levels in patients managed with two different metal‐on‐metal total hip replacements

摘要: Abstract Background : Metal-on-metal total hip prostheses will produce a certain amount of wear debris. This results in increased whole-blood metal levels, which may cause adverse effects. It is not known to what extent the problem has been overcome by advances alloy technology. Methods In 259 patients who with replacement, blood cobalt and chromium concentrations were measured atomic absorption spectrophotometry over period four years after arthroplasty. Of enrolled study, 131 had managed METASUL ® cobalt–chromium metal-on-metal bearing combination, while 128 given SIKOMET –SM21 combination. The control group consisted 31 age- gender-matched subjects. Results Compared controls, all higher levels. Cobalt up 50 times higher, 100 higher. Conclusions Both systems showed evidence, samples, debris production implants. Therefore, combinations should be carefully monitored order ensure that any local or systemic complications are detected early on.