Dimethoxycurcumin, a metabolically stable analogue of curcumin, exhibits anti-inflammatory activities in murine and human lymphocytes.

摘要: The aim of this study was to investigate whether dimethoxycurcumin (DiMC), a synthetic curcumin analogue having higher metabolic stability over curcumin, could exhibit anti-inflammatory activity in murine and human lymphocytes. Both DiMC suppressed mitogen as well antigen driven proliferation splenic Further, antigen-stimulated cytokine (IL-2, IL-4, IL-6 IFN-γ) secretion by T cells also abrogated DiMC. Interestingly, B cell induced lipopolysaccharide. Curcumin inhibited Con A-induced activation early late markers. They scavenged basal reactive oxygen species depleted GSH levels suppression mitogen-induced significantly thiol containing antioxidants suggesting role for redox their activity. the possibility directly interacting with thiol-containing antioxidant monitored changes absorbance. A NF-κB MAPK. More importantly, phytohaemagglutinin peripheral blood mononuclear cells. To explore therapeutic efficacy, they were added lymphocytes post-Con stimulation we observed significant IL-2, IFN-γ. present first time demonstrates potent find application an alternative which is currently used several clinical studies, due its superior bioavailability comparable efficacy.