Expression and prognostic significance of placental growth factor in hepatocellular carcinoma and peritumoral liver tissue

摘要: Vascular endothelial growth factor-targeted therapy is a promising treatment for hepatocellular carcinoma (HCC), but its clinical benefit often accompanied by acquired resistance. In animal studies, antiplacental factor effective with less The role of placental (PlGF) in the progression HCC not clear. our study, we used immunohistochemistry tissue microarrays to investigate PlGF expression tumor and peritumoral liver tissues from 105 patients HCC. Intratumoral mRNA was analyzed another cohort 37 patients. Peritumoral significantly higher than intratumoral (p < 0.001). associated patients' overall survival (OS) or time recurrence (TTR). However, expression, which size, presence intrahepatic metastasis, TNM stage Barcelona Clinic Liver Cancer stage, an independent risk OS = 0.026) TTR 0.041). prognostic value further validated validation (n 394). We inferred that elevation might be induced hypoxia. found hypoxia-inducible factor-1α 0.017). elevated L02, hepatic cell line, under hypoxic conditions vitro. These findings indicate high after resection could target adjuvant deserves investigations.