Common Genetic Vulnerability for Nicotine and Alcohol Dependence in Men
作者： William R. True , Hong Xian , Jeffrey F. Scherrer , Pamela A. F. Madden , Kathleen K. Bucholz
DOI: 10.1001/ARCHPSYC.56.7.655
关键词:
摘要: Results: The heritability of nicotine dependence was 60.3% (95% confidence interval [CI], 55.4%-65.2%); that alcohol dependence, 55.1% CI, 49.7%-60.5%). best-fitting model for the co-occurrence lifetime and included a substantial genetic correlation between both disorders (r = 0.68; 95% 0.61-0.74) modest unique environmental 0.23; 0.14-0.32). Conclusions: These data suggest common vulnerability to in men. This influence may partially explain clinical epidemiological observations alcoholics are often dependent smokers.
researchgate.net 
sci-hub.se 参考文章(52)
R. Monina Klevens, Gary A. Giovino, John P. Peddicord, Paul Mowery, Laurence Grummer-Strawn, David E. Nelson, The association between veteran status and cigarette-smoking behaviors. American Journal of Preventive Medicine. ,vol. 11, pp. 245- 250 ,(1995) , 10.1016/S0749-3797(18)30453-7
Mark B Sobell, Linda C Sobell, Alcohol Abuse and Smoking: Dual Recoveries. Alcohol health and research world. ,vol. 20, pp. 124- 127 ,(1996)
Richard A. Kulka, The National Vietnam veterans readjustment study : tables of findings and technical appendices Brunner/Mazel. ,(1990)
Andrew C. Heath, Pamela A. F. Madden, Genetic Influences on Smoking Behavior Springer, Boston, MA. pp. 45- 66 ,(1995) , 10.1007/978-1-4757-9377-2_3
MCCL Neale, Lon R Cardon, None, Methodology for Genetic Studies of Twins and Families ,(1992)
Andrew C Heath, Genetic Influences on Alcoholism Risk: A Review of Adoption and Twin Studies. Alcohol health and research world. ,vol. 19, pp. 166- 171 ,(1995)
John K. Hewitt, J. Rick Turner, Behavior Genetic Approaches in Behavioral Medicine Springer US. pp. 3- 13 ,(1995) , 10.1007/978-1-4757-9377-2_1
W. Henderson, C.D. Robinette, J. Goldberg, W. True, S. Eisen, The Vietnam Era Twin (VET) Registry: ascertainment bias. Acta geneticae medicae et gemellologiae. ,vol. 36, pp. 67- 78 ,(1987) , 10.1017/S0001566000004608
A C Collins, C M de Fiebre, A comparison of the development of tolerance to ethanol and cross-tolerance to nicotine after chronic ethanol treatment in long- and short-sleep mice. Journal of Pharmacology and Experimental Therapeutics. ,vol. 266, pp. 1398- 1406 ,(1993)
WILLIAM A. GROVE, Statistical Methods for Rates and Proportions, 2nd ed American Journal of Psychiatry. ,vol. 138, ,(1981) , 10.1176/AJP.138.12.1644-A