Novel Lobophorins Inhibit Oral Cancer Cell Growth and Induce Atf4- and Chop-Dependent Cell Death in Murine Fibroblasts.
作者： Patricia G. Cruz , Andrew M. Fribley , Justin R. Miller , Martha J. Larsen , Pamela J. Schultz
DOI: 10.1021/ACSMEDCHEMLETT.5B00127
关键词:
摘要: As part of the International Cooperative Biodiversity Groups (ICBG) Program, we were interested in identifying biologically active unfolded protein response (UPR) inducing compounds from marine microorganisms isolated Costa Rican biota. With this aim mind have now generated more than 33,000 unique prefractionated natural product extracts and terrestrial organisms that been submitted to Center Chemical Genomics (CCG) at University Michigan for high throughput screening (HTS). An effective complementary cell-based assay identify novel modulators UPR signaling was used extracts. Active fractions iteratively subjected reverse-phase HPLC chromatographic analysis, together with lobophorin A, B, E, F (1-4), three new congeners, designated as CR1 (5), CR2 (6), CR3 (7) isolated. Herein, report secondary assays revealed lobophorins induced UPR-associated gene expression, inhibited oral squamous cell carcinoma growth, led UPR-dependent death murine embryonic fibroblast (MEF) cells.
acs.org
sci-hub.se 参考文章(22)
Gabriella Molinari, Natural Products in Drug Discovery: Present Status and Perspectives Pharmaceutical Biotechnology. ,vol. 655, pp. 13- 27 ,(2009) , 10.1007/978-1-4419-1132-2_2
Andrew M. Fribley, Justin R. Miller, Tyler E. Reist, Michael U. Callaghan, Randal J. Kaufman, Large-scale analysis of UPR-mediated apoptosis in human cells. Methods in Enzymology. ,vol. 491, pp. 57- 71 ,(2011) , 10.1016/B978-0-12-385928-0.00004-3
Ji Xiao, Qingbo Zhang, Yiguang Zhu, Sumei Li, Guangtao Zhang, Haibo Zhang, Kumar Saurav, Changsheng Zhang, Characterization of the sugar-O-methyltransferase LobS1 in lobophorin biosynthesis Applied Microbiology and Biotechnology. ,vol. 97, pp. 9043- 9053 ,(2013) , 10.1007/S00253-013-5083-7
D. Thomas Rutkowski, Stacey M Arnold, Corey N Miller, Jun Wu, Jack Li, Kathryn M Gunnison, Kazutoshi Mori, Amir A. Sadighi Akha, David Raden, Randal J Kaufman, Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins. PLOS Biology. ,vol. 4, pp. 2024- 2041 ,(2006) , 10.1371/JOURNAL.PBIO.0040374
Alan K. Mallams, Mohindar S. Puar, Randall R. Rossman, Andrew T. McPhail, Ronald D. Macfarlane, キジャニマイシン II キジャニマイシンの構造および絶対立体化学 Journal of the American Chemical Society. ,vol. 103, pp. 3940- 3943 ,(1981) , 10.1021/JA00403A063
Caixia Chen, Jian Wang, Hui Guo, Weiyuan Hou, Na Yang, Biao Ren, Mei Liu, Huanqin Dai, Xueting Liu, Fuhang Song, Lixin Zhang, Three antimycobacterial metabolites identified from a marine-derived Streptomyces sp. MS100061. Applied Microbiology and Biotechnology. ,vol. 97, pp. 3885- 3892 ,(2013) , 10.1007/S00253-012-4681-0
Hua-Qi Pan, Song-Ya Zhang, Nan Wang, Zhan-Lin Li, Hui-Ming Hua, Jiang-Chun Hu, Shu-Jin Wang, New Spirotetronate Antibiotics, Lobophorins H and I, from a South China Sea-Derived Streptomyces sp. 12A35 Marine Drugs. ,vol. 11, pp. 3891- 3901 ,(2013) , 10.3390/MD11103891
Alan K. Mallams, Mohindar S. Puar, Randall R. Rossman, Kijanimicin. 1. Structures of the individual sugar components Journal of the American Chemical Society. ,vol. 103, pp. 3938- 3940 ,(1981) , 10.1021/JA00403A062
Ping Zhao, Jun-ya Ueda, Ikuko Kozone, Shuhei Chijiwa, Motoki Takagi, Fumitaka Kudo, Makoto Nishiyama, Kazuo Shin-ya, Tomohisa Kuzuyama, New glycosylated derivatives of versipelostatin, the GRP78/Bip molecular chaperone down-regulator, from Streptomyces versipellis 4083-SVS6. Organic and Biomolecular Chemistry. ,vol. 7, pp. 1454- 1460 ,(2009) , 10.1039/B817312E
Rong-Bian Wei, Tao Xi, Jing Li, Ping Wang, Fu-Chao Li, Yong-Cheng Lin, Song Qin, Lobophorin C and D, New Kijanimicin Derivatives from a Marine Sponge-Associated Actinomycetal Strain AZS17 Marine Drugs. ,vol. 9, pp. 359- 368 ,(2011) , 10.3390/MD9030359