Clinical pharmacokinetics of topotecan.

作者: Virginie M.M. Herben , Wim W. ten Bokkel Huinink , Jos H. Beijnen

DOI: 10.2165/00003088-199631020-00001

关键词:

摘要: … Topotecan is stable in infusion … Topotecan has been administered in phase I trials in several infusion schedules ranging from 30 minutes to 21 days. The plasma decay of topotecan …

参考文章(51)
L B Grochow, S H Kaufmann, R C Donehower, L Hurowitz, E K Rowinsky, B R Smith, F L McCabe, A DeLisa, R Johnson, S Ludeman, Pharmacokinetics and pharmacodynamics of topotecan in patients with advanced cancer. Drug Metabolism and Disposition. ,vol. 20, pp. 706- 713 ,(1992)
R G Hahn, A J Schutt, C G Moertel, R J Reitemeier, Phase II study of camptothecin (NSC-100880) in the treatment of advanced gastrointestinal cancer Cancer chemotherapy reports. ,vol. 56, pp. 95- 101 ,(1972)
B. Giovanella, J. Stehlin, M. Wall, M. Wani, A. Nicholas, L. Liu, R Silber, M Potmesil, DNA topoisomerase I--targeted chemotherapy of human colon cancer in xenografts Science. ,vol. 246, pp. 1046- 1048 ,(1989) , 10.1126/SCIENCE.2555920
H. Rosing, E. Doyle, B.E. Davies, J.H. Beijnen, High-performance liquid chromatographic determination of the novel antitumour drug topotecan and topotecan as the total of the lactone plus carboxylate forms, in human plasma Journal of Chromatography B: Biomedical Sciences and Applications. ,vol. 668, pp. 107- 115 ,(1995) , 10.1016/0378-4347(95)00054-M
W.J.M. Underberg, R.M.J. Goossen, B.R. Smith, J.H. Beijnen, Equilibrium kinetics of the new experimental anti-tumour compound SK&F 104864-A in aqueous solution. Journal of Pharmaceutical and Biomedical Analysis. ,vol. 8, pp. 681- 683 ,(1990) , 10.1016/0731-7085(90)80102-U
J.H. Beijnen, B.R. Smith, W.J. Keijer, R. Van Gijn, W.W. Ten Bokkel Huinink, L.Th. Vlasveld, S. Rodenhuis, W.J.M. Underberg, High-performance liquid chromatographic analysis of the new antitumour drug SK&F 104864-A (NSC 609699) in plasma☆ Journal of Pharmaceutical and Biomedical Analysis. ,vol. 8, pp. 789- 794 ,(1990) , 10.1016/0731-7085(90)80122-6
H. A. Burris, A.-R. Hanauske, R. K. Johnson, M. H. Marshall, J. G. Kuhn, S. G. Hilsenbeck, D. D. Von Hoff, Activity of Topotecan, a New Topoisomerase I Inhibitor, Against Human Tumor Colony-Forming Units In Vitro Journal of the National Cancer Institute. ,vol. 84, pp. 1816- 1820 ,(1992) , 10.1093/JNCI/84.23.1816
Peter J. O'Dwyer, Frank P. LaCreta, Naomi B. Haas, Teresa Halbherr, Harold Frucht, Eric Goosenberg, Kang-Shen Yao, Clinical, pharmacokinetic and biological studies of topotecan Cancer Chemotherapy and Pharmacology. ,vol. 34, pp. 46- 52 ,(1994) , 10.1007/BF00684863
Julianne Fassberg, Valentino J Stella, None, A kinetic and Mechanistic Study of the Hydrolysis of Camptothecin and Some Analogues Journal of Pharmaceutical Sciences. ,vol. 81, pp. 676- 684 ,(1992) , 10.1002/JPS.2600810718
David Kessel, H.Bruce Bosmann, Kristine Lohr, Camptothecin effects on DNA synthesis in murine leukemia cells Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis. ,vol. 269, pp. 210- 216 ,(1972) , 10.1016/0005-2787(72)90429-7