Solid-State Measurements of Drugs and Drug Formulations

摘要: Publisher Summary This chapter reviews the application of solid-state nuclear magnetic resonance (NMR) spectroscopy in studies on conformations various biomolecules and drugs pharmaceutical sciences. The method is useful for studying structure conformation, analyzing molecular motions (relaxation exchange spectroscopy), measuring internuclear distances. Assignment resonances more reliable using spectral editing two-dimensional correlation spectroscopy. It used, association with other techniques, to identify existence polymorphs act routinely as fingerprints. Powdered samples are retained their original form, tablet need only be crushed, substances isolated from plants can used further assays. Generally, when there two or molecules asymmetric unit, will observable splittings spectra due ability NMR provide detailed information about geometry. use slow MAS yielding sidebands sufficient, although principal methods involve sophisticated pulse sequences. For measurement dipolar coupling, containing simple spin systems, preferably pairs crystal structure, required. aim related computation chemical shifts enable prediction structure. In international pharmacopoeias, no example NMR, this technique especially suitable characterization may valuable tool solving regulatory problems.