Recent Insights into the Mechanism and Consequences of TRIM5α Retroviral Restriction
作者： Jaya Sastri , Edward M. Campbell
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摘要: The cellular factor TRIM5α inhibits infection by numerous retroviruses in a species-specific manner. protein from rhesus macaques (rhTRIM5α) restricts HIV-1 while human (huTRIM5α) murine leukemia virus (MLV). In owl monkeys related TRIM-Cyp infection. Several models have been proposed for retroviral restriction TRIM5 proteins (TRIM5α and TRIM-Cyp). These collectively suggest that mediate directly binding to specific determinants the viral capsid. Through their ability self-associate compartmentalize capsid core its abortive disassembly via poorly understood mechanism is sensitive proteasome inhibitors. this review, we discuss TRIM5-mediated detail. We also how polymorphisms within macaque populations demonstrated affect disease progression of immunodeficiency viruses these species.
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