Selective targeting of the αC and DFG-out pocket in p38 MAPK.
作者： Sandra Röhm , Martin Schröder , Jessica E. Dwyer , Caroline S. Widdowson , Apirat Chaikuad
DOI: 10.1016/J.EJMECH.2020.112721
关键词:
摘要: … Although it is well known that some kinases, such as ABL, ACK1, AURORA, cMET, FGFR1, MAP4K4 and p38, can adopt a folded (inactive) P-loop conformation [22], the enlarged …
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sci-hub.st 参考文章(48)
Silke M. Bauer, Jakub M. Kubiak, Ulrich Rothbauer, Stefan Laufer, From Enzyme to Whole Blood: Sequential Screening Procedure for Identification and Evaluation of p38 MAPK Inhibitors Methods of Molecular Biology. ,vol. 1360, pp. 123- 148 ,(2016) , 10.1007/978-1-4939-3073-9_10
Apirat Chaikuad, Stefan Knapp, Frank von Delft, Defined PEG smears as an alternative approach to enhance the search for crystallization conditions and crystal-quality improvement in reduced screens. Acta Crystallographica Section D-biological Crystallography. ,vol. 71, pp. 1627- 1639 ,(2015) , 10.1107/S1399004715007968
Justin Dietrich, Christopher Hulme, Laurence H. Hurley, The design, synthesis, and evaluation of 8 hybrid DFG-out allosteric kinase inhibitors: A structural analysis of the binding interactions of Gleevec®, Nexavar®, and BIRB-796 Bioorganic & Medicinal Chemistry. ,vol. 18, pp. 5738- 5748 ,(2010) , 10.1016/J.BMC.2010.05.063
Jane E. Sullivan, Geoffrey A. Holdgate, Douglas Campbell, David Timms, Stefan Gerhardt, Jason Breed, Alexander L. Breeze, Alun Bermingham, Richard A. Pauptit, Richard A. Norman, Kevin J. Embrey, Jon Read, Wendy S. VanScyoc, Walter H. J. Ward, Prevention of MKK6-dependent activation by binding to p38alpha MAP kinase. Biochemistry. ,vol. 44, pp. 16475- 16490 ,(2005) , 10.1021/BI051714V
Deborah JL Wong, Lidia Robert, Mohammad S Atefi, Amanda Lassen, Geetha Avarappatt, Michael Cerniglia, Earl Avramis, Jennifer Tsoi, David Foulad, Thomas G Graeber, Begonya Comin-Anduix, Ahmed Samatar, Roger S Lo, Antoni Ribas, Antitumor activity of the ERK inhibitor SCH722984 against BRAF mutant, NRAS mutant and wild-type melanoma Molecular Cancer. ,vol. 13, pp. 194- 194 ,(2014) , 10.1186/1476-4598-13-194
Stephen T. Wrobleski, Shuqun Lin, T.G. Murali Dhar, Alaric J. Dyckman, Tianle Li, Sidney Pitt, Rosemary Zhang, Yi Fan, Arthur M. Doweyko, John S. Tokarski, Kevin F. Kish, Susan E. Kiefer, John S. Sack, John A. Newitt, Mark R. Witmer, Murray McKinnon, Joel C. Barrish, John H. Dodd, Gary L. Schieven, Katerina Leftheris, The identification of novel p38α isoform selective kinase inhibitors having an unprecedented p38α binding mode Bioorganic & Medicinal Chemistry Letters. ,vol. 23, pp. 4120- 4126 ,(2013) , 10.1016/J.BMCL.2013.05.047
Jerry L. Adams, Jeffrey C. Boehm, Timothy F. Gallagher, Shouki Kassis, Edward F. Webb, Ralph Hall, Margaret Sorenson, Ravi Garigipati, Don E. Griswold, John C. Lee, Pyrimidinylimidazole inhibitors of p38: cyclic N-1 imidazole substituents enhance p38 kinase inhibition and oral activity. Bioorganic & Medicinal Chemistry Letters. ,vol. 11, pp. 2867- 2870 ,(2001) , 10.1016/S0960-894X(01)00570-4
John N. Low, Justo Cobo, Rodrigo Abonia, Jairo Quiroga, Christopher Glidewell, 5-Amino-3-tert-butyl-1-(4-nitrophenyl)-1H-pyrazole forms hydrogen-bonded sheets of alternating R2(2)(20) and R6(6)(32) rings. Acta Crystallographica Section C-crystal Structure Communications. ,vol. 60, ,(2004) , 10.1107/S0108270104000678
David Goldstein, Tobias Gabriel, Pathway to the clinic: inhibition of P38 MAP kinase. A review of ten chemotypes selected for development. Current Topics in Medicinal Chemistry. ,vol. 5, pp. 1017- 1029 ,(2005) , 10.2174/1568026054985939
Sanjay Kumar, Ming S. Jiang, Jerry L. Adams, John C. Lee, Pyridinylimidazole compound SB 203580 inhibits the activity but not the activation of p38 mitogen-activated protein kinase. Biochemical and Biophysical Research Communications. ,vol. 263, pp. 825- 831 ,(1999) , 10.1006/BBRC.1999.1454