Immunomostimulatory activity of aqueous extract of Azadirachta indica flowers on specific and non specific immune response.

摘要: Neem ( Azadirachta indica A. Juss) is one of the most useful traditional medicinal plants in India. flowers are traditionally used as tonic and stomachic. leaf, stem seed oil has proved immunomodulatory activity along with adverse effect on sperm count. Therefore, aim present study was to evaluate aqueous extract humoral cell mediated immune response ovalbumin, phagocytic by carbon clearance test cyclophosphamide induced myelosuppression. The also examined for ability induce secretory cellular responses murine peritoneal macrophages vitro . increased production super oxide (O 2 -) nitric (NO) macrophages. These results indicate that reactive oxygen intermediates (ROI), nitrogen (RNI) likely major mediators cytotoxic treated showed significant increase index which indicates activation reticuloendothelial system through release mediators. antibody titer against ovalbumin protection towards myelosuppression dose dependent manner. Increase immunity increasing paw edema stimulation T at 400 mg/kg. Present study, therefore, reveals holds promise agent, acts stimulating both specific (humoral immunity) non (cytotoxic macrophages).