The protective role of adenosine in inducing nitric oxide synthesis in rat liver ischemia preconditioning is mediated by activation of adenosine A2 receptors

摘要: This study aims to determine if the protective role of adenosine in liver ischemic preconditioning is mediated by activation receptors and ascertain which these implicated process. Administration A1 A2 receptor antagonists preconditioned animals indicates that hepatic receptors. Propentofylline (an inhibitor transport into cells) group, subjected previous administration an antagonist, prevented negative effect latter on protection offered preconditioning. An increase NO production was detected just immediately after preconditioning, antagonist group this increase, thus abolishing However, a donor able maintain effects. In conclusion, results indicate that, could be result extracellular adenosine. turn would induce receptors, which, eliciting generation, protect against injury associated with ischemia-reperfusion.