Expression of epidermal growth factor, transforming growth factor alpha and their receptor in gastro-oesophageal diseases.

摘要: This article is a review of aspects the expression regulatory peptides; epidermal growth factor (EGF), transforming alpha (TGF-alpha), and their receptor (EGF-R) in epithelium human oesophagus stomach health disease. It has become clear that TGF-alpha increased metaplastic, dysplastic neoplastic tissue compared with normal mucosa. The degree abnormal becomes more marked as dysplasia increases. also gastric neoplasias. EGF different pattern expression, being decreased oesophagitis gastritis. Although present Barrett's oesophagitis, does not discriminate between epithelium. EGF-R normally expressed on all gastro-intestinal epithelia, but its epithelium, well adenocarcinomas stomach. two peptides bind to receptors mucosal cell membranes, co-expression peptide positively associated varying degrees cellular proliferation. density may modulate proliferative stimulus, leading either mitogenic (regulated) or oncogenic (unregulated) growth.