Perfusion Magnetic Resonance Imaging to Assess Brain Tumor Responses to New Therapies.

摘要: BACKGROUND: Although magnetic resonance imaging (MRI) is effective in detecting the location of intracranial tumors, new techniques have been studied that may enhance specificity for prediction histologic grade tumor and distinction between recurrence necrosis associated with cancer therapy. METHODS: The authors review their experience others on use perfusion to evaluate responses brain tumors therapies. RESULTS: Functional can distinguish from normal tissue using physiological parameters. These approaches provide maps monitor effects novel compounds restrict angiogenesis. CONCLUSIONS: Perfusion MRI not only be as radionuclide-based sensitivity assessing therapies, but also offer higher resolution convenient co-registration conventional MRI, well time- cost-effectiveness. Further study needed determine role