Using Transgenic Mice to Probe the Role of Specific Genes in Behavior

摘要: This chapter will describe transgenic techniques that permit experimental manipulation of gene expression in the mouse. These create specific and permanent changes to germline mice, these strategies have been fruitfully applied study oncology, immunology, development, more recently neurobiology behavior. Specifically, area neurobiology, modification mouse has permitted direct assessment role genes development neural physiologic processes regulating Since this technique its application behavior may seem far removed from subject human psychiatric disorders, we first begin with a review some basic concepts molecular biology, followed by brief introduction place strategy context other genetic approaches studying