KIR2DS3 is associated with protection against acute myeloid leukemia.

摘要: Background: Interaction between killer cell immunoglobulin-like receptors (KIR) and human leukocyte antigen (HLA) class I molecules is important for regulation of natural (NK) function. Objective: The aim this study was to investigate the impact compound KIR-HLA genotype on susceptibility acute leukemia. Methods: Cohorts Iranian patients with myeloid leukemia (AML; n=40) lymphoid (ALL; n=38) were genotyped seventeen KIR genes their three major HLA ligand groups (C1, C2, Bw4) by a combined polymerase chain reaction–sequence-specific primers (PCR-SSP) assay. results compared those 200 healthy control individuals. Results: We found significantly decreased frequency KIR2DS3 in AML group (12.5% vs. 38%, odds ratio=0.23, p=0.0018). Also, KIR3DS1 less common than controls (27.5% 44.5%, p=0.0465, not significant after correction). Other analyses including genotypes, distribution balance inhibitory activating KIR+HLA combinations, co-inheritance pairs different group. However, trend toward more state observed. Interestingly, situation ALL inhibition enhancement through increase ligands combinations main feature Conclusion: Our findings may suggest mechanism escape leukemic cells from NK immunity.