Medicinal flowers. XV. The structures of noroleanane- and oleanane-type triterpene oligoglycosides with gastroprotective and platelet aggregation activities from flower buds of Camellia japonica.
作者： Masayuki Yoshikawa , Toshio Morikawa , Yasunobu Asao , Emi Fujiwara , Seikou Nakamura
DOI: 10.1248/CPB.55.606
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摘要: The methanolic extract from the flowers buds of Camellia japonica L. (Theaceae) were found to exhibit potent inhibitory activities on ethanol- or indomethacin-induced gastric mucosal lesions in rats. Through bioassay-guided separation, 28-noroleanane-type triterpene oligoglycosides, camelliosides A, B, and C, an oleanane-type oligoglycoside, camellioside D, isolated together with five known compounds. absolute stereostructures determined basis chemical physicochemical evidence, which included structure revision nortriterpene aglycons (camellenodiol camelledionol). principal A showed platelet aggregation activity addition gastroprotective effects
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