Presenilins and β-Amyloid Precursor Protein-Proteolytically Processed Proteins Involved in the Generation of Alzheimer’s Amyloid β Peptide
作者： C. Haass
DOI: 10.1007/978-3-642-57092-6_20
关键词:
摘要: Alzheimer’s disease (AD) is the most common dementia worldwide. In of cases, AD occurs sporadically, with an increased risk during aging. some however, mutations in three genes (see below) were found which caused early-onset familial diseases (FAD; for review, see SELKOE 1996). Furthermore, a polymorphism apoE allele major factor, that can significantly increase chance late-onset (ROSES A pathological hallmark invariant accumulation numerous senile plaques certain areas brain. Senile are composed amyloid β-peptide (Aβ), proteolytic derivative β-amyloid precursor protein (βAPP; HAASS and 1993).
springer.com
sci-hub.st 参考文章(83)
Philippe Marambaud, Karine Ancolio, Elvira Lopez-Perez, Frédéric Checler, Proteasome inhibitors prevent the degradation of familial Alzheimer's disease-linked presenilin 1 and potentiate A beta 42 recovery from human cells. Molecular Medicine. ,vol. 4, pp. 147- 157 ,(1998) , 10.1007/BF03401912
A.Y. Hung, D.J. Selkoe, Selective ectodomain phosphorylation and regulated cleavage of beta-amyloid precursor protein. The EMBO Journal. ,vol. 13, pp. 534- 542 ,(1994) , 10.1002/J.1460-2075.1994.TB06291.X
Jochen Walter, Anja Capell, Jürgen Grünberg, Brigitte Pesold, Alice Schindzielorz, Reinhard Prior, Marcia B. Podlisny, Paul Fraser, Peter St. George Hyslop, Dennis J. Selkoe, Christian Haass, The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum. Molecular Medicine. ,vol. 2, pp. 673- 691 ,(1996) , 10.1007/BF03401652
C. Haass, A.Y. Hung, M.G. Schlossmacher, D.B. Teplow, D.J. Selkoe, beta-Amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms. Journal of Biological Chemistry. ,vol. 268, pp. 3021- 3024 ,(1993) , 10.1016/S0021-9258(18)53650-4
C. Nordstedt, G.L. Caporaso, J. Thyberg, S.E. Gandy, P. Greengard, Identification of the Alzheimer beta/A4 amyloid precursor protein in clathrin-coated vesicles purified from PC12 cells. Journal of Biological Chemistry. ,vol. 268, pp. 608- 612 ,(1993) , 10.1016/S0021-9258(18)54194-6
Christian Haass, Dennis J. Selkoe, Alzheimer's disease: A technical KO of amyloid-β peptide Nature. ,vol. 391, pp. 339- 340 ,(1998) , 10.1038/34800
Bart De Strooper, Paul Saftig, Katleen Craessaerts, Hugo Vanderstichele, Gundula Guhde, Wim Annaert, Kurt Von Figura, Fred Van Leuven, Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein Nature. ,vol. 391, pp. 387- 390 ,(1998) , 10.1038/34910
Eric H. Schroeter, Jeffrey A. Kisslinger, Raphael Kopan, Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature. ,vol. 393, pp. 382- 386 ,(1998) , 10.1038/30756
Hansruedi Loetscher, Ulrich Deuschle, Manfred Brockhaus, Dieter Reinhardt, Peter Nelboeck, Jan Mous, Jürgen Grünberg, Christian Haass, Helmut Jacobsen, Presenilins are processed by caspase-type proteases. Journal of Biological Chemistry. ,vol. 272, pp. 20655- 20659 ,(1997) , 10.1074/JBC.272.33.20655
D. Levitan, T. G. Doyle, D. Brousseau, M. K. Lee, G. Thinakaran, H. H. Slunt, S. S. Sisodia, I. Greenwald, ASSESSMENT OF NORMAL AND MUTANT HUMAN PRESENILIN FUNCTION IN CAENORHABDITIS ELEGANS Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 14940- 14944 ,(1996) , 10.1073/PNAS.93.25.14940