Inhibition of protein phosphatase 5 (PP5) suppresses survival and growth of colorectal cancer cells
作者： Jianwei Wang , Jinhui Zhu , Mingjun Dong , Hua Yu , Xiaoyu Dai
DOI: 10.1002/BAB.1308
关键词:
摘要: Protein phosphatase 5 (PP5) is a unique member of the protein phosphatases family that functions in multiple signaling pathways involved DNA damage, cell cycle control, growth, and apoptosis. Recent evidence indicated PP5 may play role cancer progression. In this study, we aimed to examine biological effect on growth apoptosis human colorectal (CRC). We first knocked down expression RKO cells via short hairpin RNA containing lentivirus system. Then, methylthiazoletetrazolium assay, colony formation flow cytometry analysis were performed. The proliferation ability remarkably suppressed PP5-silenced groups, as compared with control groups. Moreover, downregulation resulted significant G0/G1 phase arrest an induction all, these results demonstrated importance CRC it might be used potential therapeutic target for treatment CRC.
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