Lupus erythematosus in the 1980s: a survey of 570 patients.

摘要: Five hundred seventy lupus erythematosus patients observed in a private practice between 1980 and 1989 were surveyed. Fifty-five percent diagnosed after 1980. three fulfilled criteria for systemic ( [SLE]; 464 idiopathic, 23 overlap, 16 drug-induced) 67 had biopsy-documented cutaneous (discoid) lupus. In the idiopathic SLE group, symptoms began at mean age of 31 years 6 years. Findings (1) 27% have family history autoimmune disease; (2) nephritis without nephrotic syndrome rarely develop renal failure (4%); (3) are relatively cyclophosphamide-resistant; (4) organ-threatening disease is present 54%; (5) 13% women who become pregnant recurrent aborters 26% never conceive. an analysis cohort data, 5- 10-year survivals 97% +/- 2% 93% 3%, respectively. Additionally, men with or thrombocytopenia poorer prognosis. Blacks similar clinical findings survival to whites. Approximately 50% deaths from active complications therapy. Prolonged has resulted new diagnostic procedures serologic tests, improved antibiotics antihypertensive agents, as well more efficacious treatment modalities.